Uses a body systems approach that combines anatomy and physiology with clincial information on basic systems of disease and pathological conditions. Two themes are applied: the complementary nature of structure and function and homeostasis and the clear, accurate description of the body when it is working properly and when it is out of balance. The integrating principle of homeostasis is used to show how normal structure and function is achieved and maintained. Failures of homeostasis are shown as basic mechanisms of disease. Included are boxed essays on exercise physiology, general interest boxes, home health care and clinical application boxes.